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ME0328

CAT: 0013-GTR19160518-01Size: 200 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19160518-01Size:200 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
ME0328 is an inhibitor of PARP-3 (IC50 = 0.89 μM) . ME0328 displays selectivity for PARP-3 over PARP-1, PARP-2 and other ARDT enzymes (IC50 values are 6.3, 10.8 and >30 μM respectively) . ME0328 also enhances CRISPR-Cas9-mediated HER2 mutation frequency, resulting in increased reduction in proliferation of HER2-positive breast cancer cells. (In Vitro) :ME0328 is a potent and selective inhibitor of ARTD3/PARP3 that is active in cells. In in vitro histone H1 modification assay, ME0328 inhibits the transferase activity of ARTD3 with an IC50 of 0.89±0.28 μM. In human A549 cells, ME0328 and ME0355 (at 10 μM) delay the resolution of γH2AX-containing foci that serve as markers for DNA double strand break repair following γ-irradiation (2 Gy) . In silico and in vitro physicochemical and metabolic profiling indicated that ME0328 is soluble, cell permeable, and metabolically stable in human liver microsomes and rat hepatocytes.
CAS Number
1445251-22-8
Product Name Alternative
ME0328 | ME 0328 | ME-0328
Purity
>98% (HPLC)
Solubility
DMSO : 75 mg/mL. 233.38 mM; H2O : < 0.1 mg/mL
Smiles
C[C@H] (NC (=O) CCC1=NC2=CC=CC=C2C (=O) N1) C1=CC=CC=C1
Molecular Formula
C19H19N3O2
Molecular Weight
321.37
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
3- (4-oxo-1H-quinazolin-2-yl) -N-[ (1S) -1-phenylethyl]propanamide

Alternative Products

CatalogName
27634-2ME0328
A14309-25ME0328 25mg
A14309-5ME0328 5mg
A14309-100ME0328 100mg
A14309-10ME0328 10mg
A14309-50ME0328 50mg
A14309-10mM-DME0328 10mM * 1mL in DMSO
454258-01ME0328 discontinued. See 255773

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