Products for Research Use Only
RegisterLogin

Cambinol

CAT: 0013-GTR19160513-02Size: 2 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0013-GTR19160513-02Size:2 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
Cambinol is a cell-permeable b-naphthol compound that inhibits the NAD-dependent deacetylase activity of SIRT1/2 (IC50: 56/59 μM, respectively) in a substrate-, but not NAD-, competitive manner. Cambinol inhibits SIRT5 deacetylase activity only at much higher concentrations (IC50 >300 μM) and no inhibitory for the class I and II HDACs. In BCL6-expressing Burkitt lymphoma cell lines, Cambinol-induced apoptosis has been attributed to the hyperacetylation of p53 and BCL6.
CAS Number
14513-15-6
Product Name Alternative
SIRT 1/2 inhibitor IV | NSC112546 | NSC-112546
Purity
>98% (HPLC)
Solubility
DMSO : 50 mg/mL. 138.72 mM; H2O : < 0.1 mg/mL
Smiles
O=c1c (Cc2c3ccccc3ccc2O) c (c2ccccc2) [nH]c (=S) [nH]1
Molecular Formula
C21H16N2O2S
Molecular Weight
360.09
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
5- ((2-hydroxynaphthalen-1-yl) methyl) -6-phenyl-2-thioxo-2,3-dihydropyrimidin-4 (1H) -one

Chemical Information

Cambinol

Cambinol is a beta-naphtol derivative that inhibits NAD-dependant deacetylases to reduce cell survival under stress. This activity is currently being investigated for its use as a cancer treatment.

CAS Number14513-15-6
PubChem CID3246390
IUPAC Name5-[(2-hydroxynaphthalen-1-yl)methyl]-6-phenyl-2-sulfanylidene-1H-pyrimidin-4-one
Molecular FormulaC21H16N2O2S
Molecular Weight360.4
XLogP4.1
Topological Polar Surface Area93.5
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count3
Rotatable Bond Count3
Heavy Atom Count26
Formal Charge0
Complexity597
SMILES
C1=CC=C(C=C1)C2=C(C(=O)NC(=S)N2)CC3=C(C=CC4=CC=CC=C43)O
InChI
InChI=1S/C21H16N2O2S/c24-18-11-10-13-6-4-5-9-15(13)16(18)12-17-19(14-7-2-1-3-8-14)22-21(26)23-20(17)25/h1-11,24H,12H2,(H2,22,23,25,26)
InChIKey
RVNSQVIUFZVNAU-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Cambinol
CAS: 14513-15-6
CID: 3246390
Formula: C21H16N2O2S
MW: 360.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight360.4
XLogP34.1
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count3
Rotatable Bond Count3
Exact Mass360.09324893
Monoisotopic Mass360.09324893
Topological Polar Surface Area93.5 Ų
Heavy Atom Count26
Formal Charge0
Complexity597
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
MBS3607300-01Cambinol
HY-100732R-01Cambinol (Standard)
A12381-5Cambinol 5mg
A12381-50Cambinol 50mg
A12381-2Cambinol 2mg
A12381-1Cambinol 1mg
A12381-500Cambinol 500mg
A12381-25Cambinol 25mg
A12381-100Cambinol 100mg
A12381-10Cambinol 10mg

Popular Products