Products for Research Use Only
RegisterLogin

G-749

CAT: 0013-GTR19160509-01Size: 1 gDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0013-GTR19160509-01Size:1 g
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
G-749 is a novel FLT3 inhibitor that showed potent and sustained inhibition of the FLT3 wild type and mutants including FLT3-ITD, FLT3-D835Y, FLT3-ITD/N676D, and FLT3-ITD/F691L in cellular assays. G-749 retained its inhibitory potency in various drug-resistance milieus such as patient plasma, FLT3 ligand surge, and stromal protection. Furthermore, it displayed potent antileukemic activity in bone marrow blasts from AML patients regardless of FLT3 mutation status, including those with little or only minor responses to AC220 or PKC412. Oral administration of G-749 yielded complete tumor regression and increased life span in animal models. Thus, G-749 appears to be a promising next-generation drug candidate for the treatment of relapsed and refractory AML patients with various FLT3-ITD/FLT3-TKD mutants and further shows the ability to overcome drug resistance.
CAS Number
1457983-28-6
Product Name Alternative
Alpha-MCPG
Purity
>98% (HPLC)
Solubility
DMSO : 25 mg/mL; 47.95 mM
Smiles
CN1CCC (CC1) NC1=NC2=C (C (=O) NC=C2Br) C (NC2=CC=C (OC3=CC=CC=C3) C=C2) =N1
Molecular Formula
C25H25BrN6O2
Molecular Weight
521.41
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
8-bromo-2- ((1-methylpiperidin-4-yl) amino) -4- ((4-phenoxyphenyl) amino) pyrido[4,3-d]pyrimidin-5 (6H) -one

Related Products

CatalogName
GTR19276882-01CRBN ligand-749
GTR19233656-01G-4'G-7S
GTR18874443-01Protein G (protein G)
GTR19067934-01Adipokinetic Hormone, G (AKH-G)
GTR18777371-01VSV G/Glycoprotein G Antibody
GTR19067939-01A-A-A-Y-G-G-F-L
GTR18575714Anti-HLA-G [mem-G/9]
GTR19068193-01R-G-Y-S-L-G
GTR19067299-01Protein Kinase G Substrate; G-Subtide
GTR19021120Recombinant Nipah virus Glycoprotein G (G)

Alternative Products

CatalogName
A8889-1G-749
MBS131132-01G 749
A14214-200G-749 200mg
A14214-5G-749 5mg
A14214-500G-749 500mg
A14214-50G-749 50mg
A14214-25G-749 25mg
A14214-10G-749 10mg
A14214-1G-749 1mg
T70597-01G-749 hydrochloride

Popular Products