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CA-074 methyl ester

CAT: 0013-GTR19160503-01Size: 200 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19160503-01Size:200 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Ca-074Me is a selective and cell-permeable inhibitor of cathepsin B. (In Vitro) :CA-074Me (5 μM and 50 μM) inhibits RANKL-induced osteoclastogenesis in BMM cells derived from C57BL/6J and NOD/ShiLtJ mice. CA-074Me exerts its anti-osteoclastogenic effect within 24 hours post-RANKL stimulation in vitro. CA-074Me does not exert its anti-osteoclastogenic effect via the MAPK-ERK signaling cascade. CA-074Me inhibits c-FOS upregulation and subsequent NFATc1 autoamplification following RANKL stimulation.. CA-074Me reduces apoptosis induced by CVB1. (In Vivo) :Hippocampal CA1 neuronal programmed necrosis induced by global cerebral I/R injury is prevented by CA074-me (1 μg, 10 μg) both pre-treatment and post-treatment. The rupture of lysosomal membrane and the leakage of cathepsin-B, and this is strongly inhibited by CA074-me pre-treatment. The overexpression and nuclear translocation of RIP3 and the reduction of NAD+ level after I/R injury are also inhibited, while the upregulation of Hsp70 is strengthened by CA074-me pre-treatment. CA-074Me (30 mg/kg) is capable of inhibiting osteoclastogenesis and bone degradation in vivo. In the CVB+CA-074Me (4 mg/kg/day i.m.) guinea pigs group, the scores of inflammation significantly decrease in comparison with the CVB+None group. In CVB+CA-074Me group, the number of CD8+T cells decrease in comparison with the sham group.
CAS Number
147859-80-1
Product Name Alternative
LY300046
Purity
>98% (HPLC)
Solubility
DMSO : ≥ 215 mg/mL. 540.92 mM; H2O : 26.66 mg/mL. 67.07 mM
Smiles
CCCNC (=O) [C@@H]1[C@H] (O1) C (=O) N[C@@H] ([C@@H] (C) CC) C (=O) N1CCC[C@@H]1C (=O) OC
Molecular Formula
C19H31N3O6
Molecular Weight
397.5
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
N- (L-3-trans-Propylcarbonyl-oxirane-2-carbonyl) -L-isoleucyl-L-proline methyl ester

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