Products for Research Use Only

FIIN-2

CAT: 0013-GTR19160469-01Size: 200 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19160469-01Size:200 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
FIIN-2 is a potent, selective, irreversible and the next-generation covalent FGFR inhibitor. FIIN-2 is the first inhibitor that can potently inhibit the proliferation of cells dependent upon the gatekeeper mutants of FGFR1 or FGFR2, which confer resistance to first-generation clinical FGFR inhibitors such as NVP-BGJ398 and AZD4547. FIIN-2 also binds in the DFG-out mode despite lacking a functional group necessary to occupy the pocket vacated upon the DFG-out flip.
CAS Number
1633044-56-0
Product Name Alternative
FIIN2 | FIIN 2 | FIIN-2
Purity
>98% (HPLC)
Solubility
DMSO : ≥ 30 mg/mL 47.26 mM
Smiles
CN1CCN (CC1) c1ccc (cc1) Nc1ncc2CN (C (=O) N (c2n1) Cc1ccc (cc1) NC (=O) C=C) c1cc (cc (c1) OC) OC
Molecular Formula
C35H38N8O4
Molecular Weight
634.73
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
N- (4- ((3- (3,5-dimethoxyphenyl) -7- ((4- (4-methylpiperazin-1-yl) phenyl) amino) -2-oxo-3,4-dihydropyrimido[4,5-d]pyrimidin-1 (2H) -yl) methyl) phenyl) acrylamide

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