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BQU57

CAT: 0013-GTR19160465-01Size: 200 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19160465-01Size:200 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
BQU57 is a GTPase Ral inhibitor. The Ras-like GTPases RalA and RalB are important drivers of tumour growth and metastasis. Chemicals that block Ral function would be valuable as research tools and for cancer therapeutics. The binding of the RBC8 derivative BQU57 to RalB was confirmed by isothermal titration calorimetry, surface plasmon resonance and (1) H- (15) N transverse relaxation-optimized spectroscopy (TROSY) NMR spectroscopy. RBC8 and BQU57 show selectivity for Ral relative to the GTPases Ras and RhoA and inhibit tumour xenograft growth to a similar extent to the depletion of Ral using RNA interference. The utility of structure-based discovery for the development of therapeutics for Ral-dependent cancers.
CAS Number
1637739-82-2
Product Name Alternative
BQU57 | BQU 57 | BQU-57
Purity
>98% (HPLC)
Solubility
DMSO : ≥ 36 mg/mL; 107.69 mM
Smiles
Cc1nn (c2c1C (C (=C (O2) N) C#N) c1ccc (cc1) C (F) (F) F) C
Molecular Formula
C16H13F3N4O
Molecular Weight
334.3
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
6-amino-1,3-dimethyl-4- (4- (trifluoromethyl) phenyl) -1,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile

Alternative Products

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S7607-25mgBQU57
A14956-5BQU57 5mg
A14956-200BQU57 200mg
A14956-50BQU57 50mg
A14956-10BQU57 10mg
A14956-100BQU57 100mg

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