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Desmethylanethol trithione

CAT: 0013-GTR19160431-01Size: 200 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19160431-01Size:200 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
ADT-OH is a derivative of anethole dithiolethione (ADT) and synthetic hydrogen sulfide (H2S) donor. In the in vitro glucose-oxygen deprivation (OGD) model, ADT-OH markedly attenuated tPA-enhanced Akt activation and VEGF expression in brain microvascular endothelial cells. Finally, ADT-OH improved functional outcomes in mice subjected to MCAO and tPA infusion. H2S donors reduced tPA-induced cerebral hemorrhage by possibly inhibiting the Akt-VEGF-MMP9 cascade. Administration of H2S donors has potential as a novel modality to improve the safety of tPA following stroke.
CAS Number
18274-81-2
Product Name Alternative
ADT-OH | Desmethylanethol trithione | ACS1
Purity
>98% (HPLC)
Solubility
In Vitro: DMSO : 125 mg/mL (552.27 mM)
Smiles
C1cc (O) ccc1c1cc (=S) ss1
Molecular Formula
C9H6OS3
Molecular Weight
226.33
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
5- (4-hydroxyphenyl) -3H-1,2-dithiole-3-thione

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