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PD168393

CAT: 0013-GTR19160415-05Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19160415-05Size:5 mg
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Description
PD-168393 is a potent, cell-permeable, irreversible, ATP-competitive and selective inhibitor of EGF receptor (EGFR) tyrosine kinase activity (IC50 = 700 pM) .
CAS Number
194423-15-9
Product Name Alternative
PD168393 | PD 168393 | PD-168393
Purity
>98% (HPLC)
Solubility
DMSO : ≥ 30 mg/mL. 81.25 mM
Smiles
C=CC (=O) Nc1cc2c (cc1) ncnc2Nc1cc (ccc1) Br
Molecular Formula
C17H13BrN4O
Molecular Weight
369.22
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
4-[ (3-Bromophenyl) amino]-6-acrylamidoquinazoline

Chemical Information

Pd 168393

PD 168393 is a member of the class of quinazolines carrying bromoanilino and acrylamido substituents at positions 4 and 6 respectively. It has a role as an epidermal growth factor receptor antagonist. It is a secondary carboxamide, a member of acrylamides, a member of bromobenzenes, a member of quinazolines and a substituted aniline.

CAS Number194423-15-9
PubChem CID4708
IUPAC NameN-[4-(3-bromoanilino)quinazolin-6-yl]prop-2-enamide
Molecular FormulaC17H13BrN4O
Molecular Weight369.2
XLogP3.9
Topological Polar Surface Area66.9
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count4
Rotatable Bond Count4
Heavy Atom Count23
Formal Charge0
Complexity433
SMILES
C=CC(=O)NC1=CC2=C(C=C1)N=CN=C2NC3=CC(=CC=C3)Br
InChI
InChI=1S/C17H13BrN4O/c1-2-16(23)21-13-6-7-15-14(9-13)17(20-10-19-15)22-12-5-3-4-11(18)8-12/h2-10H,1H2,(H,21,23)(H,19,20,22)
InChIKey
HTUBKQUPEREOGA-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Pd 168393
CAS: 194423-15-9
CID: 4708
Formula: C17H13BrN4O
MW: 369.2
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight369.2
XLogP33.9
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count4
Rotatable Bond Count4
Exact Mass368.02727
Monoisotopic Mass368.02727
Topological Polar Surface Area66.9 Ų
Heavy Atom Count23
Formal Charge0
Complexity433
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
A2024-5PD168393
A12725-10PD168393 10mg
A12725-2PD168393 2mg
A12725-1PD168393 1mg
A12725-100PD168393 100mg
A12725-25PD168393 25mg
A12725-5PD168393 5mg
A12725-50PD168393 50mg
SF5418-5mgPD168393 (EGFR inhibitor)

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