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Dalcetrapib

CAT: 0013-GTR19160399-01Size: 200 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19160399-01Size:200 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Dalcetrapib, aslo known as JTT-705, is a CETP inhibitor. The drug was aimed at raising the blood levels of "good cholesterol" (cholesterol carried in HDL particles, aka HDL-C) . Prevailing observations indicate that high HDL levels correlate with better overall cardiovascular health, though it remains unclear whether raising HDL levels consequently leads to an increase in cardiovascular health. Development of this drug was halted on May 7, 2012 “due to a lack of clinically meaningful efficacy. (In Vitro) :Dalcetrapib (JTT-705) (0.1-10 μM; 21 h) dose-dependently increases pre-β-HDL formation.Dalcetrapib (0-30 μM; 24 h) inhibits the CETP activity of media in HepG2 in a dose-dependent manner. (In Vivo) :Dalcetrapib (JTT-705) (30 or 100 mg/kg; p.o.; once a day for 3 days) increases plasma HDL cholesterol in rabbits.Dalcetrapib (100 mg/kg; i.g.; twice daily for 7 days) significantly increases fecal elimination of neutral sterols, bile acids, and plasma HDL-cholesterol.
CAS Number
211513-37-0
Product Name Alternative
JTT-705 | JTT705 | JTT 705 | RO-4607381
Purity
>98% (HPLC)
Solubility
DMSO : ≥ 50 mg/mL. 128.34 mM; H2O : < 0.1 mg/mL
Smiles
C1 (ccccc1NC (=O) C1 (CC (CC) CC) CCCCC1) SC (=O) C (C) C
Molecular Formula
C23H35NO2S
Molecular Weight
389.59
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
S-[2-[[1- (2-ethylbutyl) cyclohexanecarbonyl]amino]phenyl] 2-methylpropanethioate

Alternative Products

CatalogName
HY-14950-01Dalcetrapib
HY-14950R-01Dalcetrapib (Standard)
2532-1EZSolution ™ Dalcetrapib
C17056-10mM/1mLDalcetrapib (JTT-705)
SD7207-5mgDalcetrapib (CETP inhibitor)

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