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Madrasin

CAT: 0013-GTR19160338-02Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19160338-02Size:5 mg
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Description
Madrasin is a potent and cell penetrant splicing inhibitor that interferes with the early stages of spliceosome assembly. Madrasin stalls spliceosome assembly at the A complex. (In Vitro) :Madrasin (10-30 μM; 4-24 hours; HeLa cells) treatment inhibits the splicing of each of the RIOK3, BRD2, and Hsp40, MCL1, CCNA2, AURKA and p27 pre-mRNAs in both HeLa and HEK293 cells.Madrasin (10-30 μM; 4-24 hours; HeLa and HEK293 cells) treatment shows a dose- and time-dependent inhibitory effect on cell cycle progression.
CAS Number
374913-63-0
Product Name Alternative
DDD00107587 | Madrasin. RNA splicing inhibitor
Purity
>98% (HPLC)
Solubility
H2O : < 0.1 mg/mL
Smiles
O=c1[nH]c (Nc2nc (C) c3ccc (OC) cc3n2) nc (C) c1C
Molecular Formula
C16H17N5O2
Molecular Weight
311.34
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
2- ((7-Methoxy-4-methylquinazolin-2-yl) amino) -5,6-dimethylpyrimidin-4 (3H) -one

Chemical Information

Madrasin

2-[(7-methoxy-4-methyl-2-quinazolinyl)amino]-5,6-dimethyl-1H-pyrimidin-4-one is a member of quinazolines.

CAS Number374913-63-0
PubChem CID135444382
IUPAC Name2-[(7-methoxy-4-methylquinazolin-2-yl)amino]-4,5-dimethyl-1H-pyrimidin-6-one
Molecular FormulaC16H17N5O2
Molecular Weight311.34
XLogP1.7
Topological Polar Surface Area88.5
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count5
Rotatable Bond Count3
Heavy Atom Count23
Formal Charge0
Complexity545
SMILES
CC1=C(N=C(NC1=O)NC2=NC(=C3C=CC(=CC3=N2)OC)C)C
InChI
InChI=1S/C16H17N5O2/c1-8-9(2)17-16(20-14(8)22)21-15-18-10(3)12-6-5-11(23-4)7-13(12)19-15/h5-7H,1-4H3,(H2,17,18,19,20,21,22)
InChIKey
QQJIYKXTEMDJFM-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Madrasin
CAS: 374913-63-0
CID: 135444382
Formula: C16H17N5O2
MW: 311.34
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight311.34
XLogP31.7
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count5
Rotatable Bond Count3
Exact Mass311.13822480
Monoisotopic Mass311.13822480
Topological Polar Surface Area88.5 Ų
Heavy Atom Count23
Formal Charge0
Complexity545
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
B1278-25Madrasin
A16063-10Madrasin 10mg
A16063-5Madrasin 5mg
A16063-50Madrasin 50mg
A16063-25Madrasin 25mg
A16063-100Madrasin 100mg
A16063-1Madrasin 1mg
A16063-500Madrasin 500mg

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