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Jervine

CAT: 0013-GTR19160325-01Size: 1 gDry Ice: NoHazardous: No
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CAT#:0013-GTR19160325-01Size:1 g
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
The biological activity of Jervine is mediated via its interaction with the 7 passes transmembrane protein Smoothened. Jervine binds with and inhibits smoothened, which is an integral part of the Hedgehog signaling pathways. With smoothened inhibited, the GLI1 transcription cannot be activated and Hedgehog target genes cannot be transcribed.
CAS Number
469-59-0
Product Name Alternative
11-Ketocyclopamine
Purity
>98% (HPLC)
Solubility
DMSO : 1 mg/mL2.35 mM
Smiles
O=C1C2=C (C) [C@]3 (CC[C@H]2[C@@H]2CC=C4C[C@H] (CC[C@]4 (C) [C@@H]12) O) O[C@@H]1C[C@@H] (CN[C@H]1[C@H]3C) C
Molecular Formula
C27H39NO3
Molecular Weight
425.61
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.

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