Products for Research Use Only

Alvelestat

CAT: 0013-GTR19160231-01Size: 1 gDry Ice: NoHazardous: No
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CAT#:0013-GTR19160231-01Size:1 g
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Avelestat, also known as AZD9668 and MPH-966, is a novel, oral inhibitor of neutrophil elastase (NE), an enzyme implicated in the signs, symptoms, and disease progression in NE-driven respiratory diseases such as bronchiectasis and chronic obstructive pulmonary disease via its role in the inflammatory process, mucus overproduction, and lung tissue damage. In cell-based assays, AZD9668 inhibited plasma NE activity in zymosan-stimulated whole blood. AZD9668 has the potential to reduce lung inflammation and the associated structural and functional changes in human diseases.
CAS Number
848141-11-7
Product Name Alternative
AZD-9668 | MPH966 | Alvelestat
Purity
>98% (HPLC)
Solubility
DMSO : ≥ 33 mg/mL; 60.49 mM
Smiles
C1 (n (c (=O) c (cc1c1n (ncc1) C) C (=O) NCc1ccc (cn1) S (=O) (=O) C) c1cc (ccc1) C (F) (F) F) C
Molecular Formula
C25H22F3N5O4S
Molecular Weight
545.53
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
6-methyl-5- (1-methyl-1H-pyrazol-5-yl) -N- ((5- (methylsulfonyl) pyridin-2-yl) methyl) -2-oxo-1- (3- (trifluoromethyl) phenyl) -1,2-dihydropyridine-3-carboxamide