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Aftin-4

CAT: 0013-GTR19160211-01Size: 200 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19160211-01Size:200 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Aftin-4, an amyloid forty-two inducer, activates γ-secretase, promoting the generation of amyloid-β-1-42 (Aβ1-42) from amyloid-β protein precursor. Aftin-4 increased Aβ-1-42, but not Aβ-1-40 in mouse hipppocampus, accompanied by learning deficits and mitochondrial ultrastructural changes similar to those found in the brains of patients with AD. Aftin-4 can thus be used to induce a rapid, acute Alzheimer's disease-like toxicity in the rodent brain.
CAS Number
866893-90-5
Product Name Alternative
Aftin-4 | Aftin 4 | Aftin4
Purity
>98% (HPLC)
Solubility
DMSO : ≥ 250 mg/mL; 678.46 mM
Smiles
CC[C@H] (CO) Nc2nc1c (ncn1C (C) C) c (n2) N (C) Cc3ccccc3
Molecular Formula
C20H28N6O
Molecular Weight
368.48
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
(R) -2-[6- (Benzyl-methyl-amino) -9-isopropyl-9H-purin-2-ylamino]-butan-1-ol

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BA8413-50Aftin-4
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