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SC75741

CAT: 0013-GTR19160187-01Size: 1 gDry Ice: NoHazardous: No
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CAT#:0013-GTR19160187-01Size:1 g
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
SC75741 is a NF-kappaB inhibitor. SC75741 protects mice against highly pathogenic avian influenza A virus. SC75741 significantly protects mice against infection with highly pathogenic avian influenza A viruses of the H5N1 and H7N7 subtypes. SC75741 efficiently blocks influenza virus propagation and confers a high barrier for development of viral resistance. (In Vitro) :SC75741 (5 μM; 24-96 hours) inhibits long-term A549 cells proliferation.SC75741 (1-10 μM; 5.5-65 hours) reduces A549 cells viability in a concentration-dependent manner indicating a cytostatic effect for A549 cells within a time frame of about 50 and 65 hours.SC75741 (5 μM; 24 hours) strongly inhibits cleavage of the effector caspase 3 induced upon H7N7-infection. (In Vivo) :SC75741 (intraperitoneal injection; 15 mg/kg; for 2 days) leads to a reduced propagation of the H5N1 virus mRNA by 90% in the lungs of infected mice.The plasma-levels of SC74751 (intravenously of 5 mg/kg and intraperitoneally of 15 mg/kg; for 3.5 and 6 hours) after i.v. administration decreases mono-exponentially and half-life is roughly 40 min. After i.p. administration, elimination of SC75741 seems to be limited by a slow uptake from the peritoneum and a half-life of 55 min is observed.
CAS Number
913822-46-5
Product Name Alternative
SC75741 | SC-75741 | SC 75741
Purity
>98% (HPLC)
Solubility
DMSO : ≥ 125 mg/mL; 220.98 mM
Smiles
O=C (NC1=NC2=CC=C (C=C2N1) C (=O) C1=CC=CC=C1) C1=CSC (=N1) C1CCN (CC1) C1=C2SC=CC2=NC=N1
Molecular Formula
C29H23N7O2S2
Molecular Weight
565.67
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
N- (6-benzoyl-1H-benzimidazol-2-yl) -2- (1-thieno[3,2-d]pyrimidin-4-yl-4-piperidinyl) -4-thiazolecarboxamide

Alternative Products

CatalogName
B4749-10SC75741
A14278-50SC75741 50mg
A14278-25SC75741 25mg
A14278-10SC75741 10mg
A14278-5SC75741 5mg
A14278-100SC75741 100mg

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