Products for Research Use Only
RegisterLogin

A-966492

CAT: 0013-GTR19160174-01Size: 200 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0013-GTR19160174-01Size:200 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
A-966492 is a potent PARP inhibitor, which displayed excellent potency against the PARP-1 enzyme with a K (i) of 1 nM and an EC (50) of 1 nM in a whole cell assay. In addition, A-966492 is orally bioavailable across multiple species, crosses the blood-brain barrier, and appears to distribute into tumor tissue. It also demonstrated good in vivo efficacy in a B16F10 subcutaneous murine melanoma model in combination with temozolomide and in an MX-1 breast cancer xenograft model both as a single agent and in combination with carboplatin.
CAS Number
934162-61-5
Product Name Alternative
A966492 | A 966492 | A-966492
Purity
>98% (HPLC)
Solubility
DMSO : ≥ 100 mg/mL308.31 mM
Smiles
NC (=O) c1c2[nH]c (nc2ccc1) c1ccc (cc1F) [C@@H]1CCCN1
Molecular Formula
C18H17FN4O
Molecular Weight
324.35
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
(S) -2- (2-fluoro-4- (pyrrolidin-2-yl) phenyl) -1H-benzimidazole-4-carboxamide

Related Products

CatalogName
GTR19172661-01GW-9662
GTR19162735-01GW 9662

Alternative Products

CatalogName
A4160-10A-966492
FA100934-01A 966492

Popular Products