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A922500

CAT: 0013-GTR19160151-08Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19160151-08Size:50 mg
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Description
A-922500 is a potent orally active inhibitor of DGAT-1 activity, inhibiting both human and mouse forms of the enzymes with IC50 values of 7 and 24 nM, respectively. Acyl CoA/diacylglycerol acyltransferase (DGAT) 1 is one of two known DGAT enzymes that catalyze the final and only committed step in triglyceride biosynthesis.
CAS Number
959122-11-3
Product Name Alternative
A-922500 | A 922500 | A922500
Purity
>98% (HPLC)
Solubility
DMSO : ≥ 50 mg/mL; 116.69 mM
Smiles
OC (=O) [C@@H]1CCC[C@H]1C (=O) C1=CC=C (C=C1) C1=CC=C (NC (=O) NC2=CC=CC=C2) C=C1
Molecular Formula
C26H24N2O4
Molecular Weight
428.48
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
(1R,2R) -2- (4'- (3-phenylureido) -[1,1'-biphenyl]-4-carbonyl) cyclopentane-1-carboxylic acid

Chemical Information

(1R,2R)-2-((4'-(((Phenylamino)carbonyl)amino)(1,1'-biphenyl)-4-yl)carbonyl)cyclopentanecarboxylic acid

A 922500 is an aromatic ketone.

CAS Number959122-11-3
PubChem CID24768261
IUPAC Nametrans-(1R,2R)-2-[4-[4-(phenylcarbamoylamino)phenyl]benzoyl]cyclopentane-1-carboxylic acid
Molecular FormulaC26H24N2O4
Molecular Weight428.5
XLogP4.3
Topological Polar Surface Area95.5
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count4
Rotatable Bond Count6
Heavy Atom Count32
Formal Charge0
Complexity659
SMILES
C1C[C@H]([C@@H](C1)C(=O)O)C(=O)C2=CC=C(C=C2)C3=CC=C(C=C3)NC(=O)NC4=CC=CC=C4
InChI
InChI=1S/C26H24N2O4/c29-24(22-7-4-8-23(22)25(30)31)19-11-9-17(10-12-19)18-13-15-21(16-14-18)28-26(32)27-20-5-2-1-3-6-20/h1-3,5-6,9-16,22-23H,4,7-8H2,(H,30,31)(H2,27,28,32)/t22-,23-/m1/s1
InChIKey
BOZRFEQDOFSZBV-DHIUTWEWSA-N
Chemical Structure
2D Structure
2D structure of (1R,2R)-2-((4'-(((Phenylamino)carbonyl)amino)(1,1'-biphenyl)-4-yl)carbonyl)cyclopentanecarboxylic acid
CAS: 959122-11-3
CID: 24768261
Formula: C26H24N2O4
MW: 428.5
Interactive 3D Structure
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View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight428.5
XLogP34.3
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count4
Rotatable Bond Count6
Exact Mass428.17360725
Monoisotopic Mass428.17360725
Topological Polar Surface Area95.5 Ų
Heavy Atom Count32
Formal Charge0
Complexity659
Isotope Atom Count0
Defined Atom Stereocenter Count2
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
A4382-50A922500

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