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Rg3039

CAT: 0013-GTR19160118-01Size: 1 gDry Ice: NoHazardous: No
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CAT#:0013-GTR19160118-01Size:1 g
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
RG3039, also known as PF-06687859, is a potent DcpS inhibitor. DcpS is a therapeutic target for spinal muscular atrophy. Spinal muscular atrophy (SMA) is caused by deletion or mutation of both copies of the SMN1 gene which produces an essential protein known as SMN. RG3039 improves motor function in SMA mice. RG3039 also showed activity to improve survival, function and motor unit pathologies in two SMA mouse models.
CAS Number
1005504-62-0
Product Name Alternative
RG3039 | RG 3039 | PF 06687859 | PF-06687859
Purity
>98% (HPLC)
Solubility
DMSO : 6 mg/mL 13.88 mM; H2O : < 0.1 mg/mL
Smiles
C1CN (CCC1COc1cccc2c1c (nc (n2) N) N) Cc1c (cccc1Cl) Cl
Molecular Formula
C21H23Cl2N5O
Molecular Weight
432.35
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
5- ((1- (2,6-dichlorobenzyl) piperidin-4-yl) methoxy) quinazoline-2,4-diamine

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A13835-500Rg3039 (PF-06687859) 500mg
A13835-100Rg3039 (PF-06687859) 100mg
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