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SAR131675 (b)

CAT: 0013-GTR19160056-01Size: 200 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19160056-01Size:200 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
SAR131675 is a potent and selective VEGFR-3 inhibitor. It inhibited VEGFR-3 tyrosine kinase activity and VEGFR-3 autophosphorylation in HEK cells with IC (50) values of 20 and 45 nmol/L, respectively. SAR131675 was found to be highly selective for VEGFR-3 versus 107 receptors, enzymes, ion channels, and 65 kinases. SAR131675 is the first highly specific VEGFR-3-TK inhibitor described to date, displaying significant antitumoral and antimetastatic activities in vivo through inhibition of lymphangiogenesis and TAM invasion.
CAS Number
1092539-44-0
Product Name Alternative
SAR131675 | SAR 131675 | SAR-131675
Purity
>98% (HPLC)
Smiles
CCn1c (c (c (=O) c2c1nc (cc2) C#CC (C) (COC) O) C (=O) NC) N
Molecular Formula
C18H22N4O4
Molecular Weight
358.16
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
2-amino-1-ethyl-7- (3-hydroxy-4-methoxy-3-methylbut-1-yn-1-yl) -N-methyl-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxamide

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