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Acetyl shikonin

CAT: 0013-GTR19159821-01Size: 100 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19159821-01Size:100 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Acetylshikonin exhibits weak cytotoxicity against human umbilical vein endothelial cells (HUVECs) with IC5 of over 2 microM, exhibits the antiangiogenic and antitumorigenic effects by suppressing proliferation and angiogenic factors. Acetylshikonin inhibits the generation of NADPH oxidase complex in the activation of respiratory burst of PMNs, but does not directly inhibit the activity of NADPH oxidase already generated. Certain shikonin derivatives (such as Acetyl shikonin) act as modulators of the Nur77-mediated apoptotic pathway and identify a new shikonin-based lead that targets Nur77 for apoptosis induction. Acetylshikonin, shikonin, and alkannin have accelerative effect on the proliferation of granulation tissue in rats. Acetylshikonin has inhibitory effect on the edematous response is due neither to the release of steroid hormones from the adrenal gland nor to the glucocorticoid activity, but probably partly to the suppression of mast cell degranulation and partly to protection of the vasculature from mediator challenge. Acetylshikonin induces apoptosis of hepatitis B virus X protein-expressing human hepatocellular carcinoma cells via endoplasmic reticulum stress.
CAS Number
24502-78-1
Purity
>98% (HPLC)
Solubility
In Vitro: DMSO : 50 mg/mL (151.36 mM)
Smiles
CC (=CCC (C1=CC (=O) C2=C (C=CC (=C2C1=O) O) O) OC (=O) C) C
Molecular Formula
C18H18O6
Molecular Weight
330.33
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.

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