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Avibactam sodium

CAT: 0013-GTR19159775-01Size: 1 gDry Ice: NoHazardous: No
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CAT#:0013-GTR19159775-01Size:1 g
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Avibactam is a reversible β-lactamase inhibitor (IC50: 8/80/38 nM, for TEM-1/P99/KPC-2 β-lactamases) . (In Vitro) :Avibactam is a molecule with little antibacterial activity, that inhibits class A and C β-lactamases, but not metallo types and Acinetobacter OXA carbapenemases.Ceftazidime (HY-B0593) -Avibactam (0-256 mg/L) inhibits 16 blaKPC-2 positive and 1 of blaOXA-232 positive Klebsiella pneumonia growth with MIC50 and MIC90 for both 8 mg/L. (In Vivo) :Ceftazidime-Avibactam (0.375 mg/g; s.c.; q8h for 10 days) has a significant effect on the bacteria and led to a certain therapeutic efficacy in K. pneumoniae strain Y8 infected mouse model.Avibactam (64 mg/kg; s.c.; once) shows mean estimated half-life in plasma in the terminal phase of 0.24 h in Pseudomonas aeruginosa infected neutropenic mice with lung infection.
CAS Number
1192491-61-4
Product Name Alternative
NXL-104
Field of Research
Pharmacology & Drug Discovery
Purity
>98% (HPLC)
Solubility
H2O : ≥ 145 mg/mL 504.82 mM; DMSO : ≥ 30 mg/mL 104.45 mM
Smiles
C1C[C@H] (N2C[C@@H]1N (C2=O) OS (=O) (=O) [O-]) C (=O) N.[Na+]
Molecular Formula
C7H10N3NaO6S
Molecular Weight
287.22
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.

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