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SRT3109

CAT: 0013-GTR19159759-04Size: 2 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19159759-04Size:2 mg
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Description
SRT3109 is a CXCR2 ligand. CXCR2 ligands are potent chemoattractants for neutrophils and play a key role in the emigration of neutrophils from the blood to sites of tissue inflammation. Moreover, CXCR2 signaling may also regulate neutrophil mobilization from the bone marrow. Deletion of the chemokine receptor CXCR2 prevents the recruitment of neutrophils into tissues and subsequent development of experimental Lyme arthritis.
CAS Number
1204707-71-0
Product Name Alternative
SRT3109 | SRT-3109
Purity
>98% (HPLC)
Solubility
DMSO : ≥ 100 mg/mL; 210.29 mM
Smiles
C[C@H] ([C@H] (CO) O) Nc1cc (nc (n1) SCc1c (c (ccc1) F) F) NS (=O) (=O) N1CCC1
Molecular Formula
C18H23F2N5O4S2
Molecular Weight
475.53
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
N- (2- ((2,3-difluorobenzyl) thio) -6- (((2R,3R) -3,4-dihydroxybutan-2-yl) amino) pyrimidin-4-yl) azetidine-1-sulfonamide

Chemical Information

Azd-5122

a CXCR2 receptor antagonist; structure in first source

CAS Number1204707-71-0
PubChem CID44602493
IUPAC NameN-[2-[(2,3-difluorophenyl)methylsulfanyl]-6-[[(2R,3R)-3,4-dihydroxybutan-2-yl]amino]pyrimidin-4-yl]azetidine-1-sulfonamide
Molecular FormulaC18H23F2N5O4S2
Molecular Weight475.5
XLogP2.1
Topological Polar Surface Area161
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count12
Rotatable Bond Count10
Heavy Atom Count31
Formal Charge0
Complexity670
SMILES
C[C@H]([C@H](CO)O)NC1=CC(=NC(=N1)SCC2=C(C(=CC=C2)F)F)NS(=O)(=O)N3CCC3
InChI
InChI=1S/C18H23F2N5O4S2/c1-11(14(27)9-26)21-15-8-16(24-31(28,29)25-6-3-7-25)23-18(22-15)30-10-12-4-2-5-13(19)17(12)20/h2,4-5,8,11,14,26-27H,3,6-7,9-10H2,1H3,(H2,21,22,23,24)/t11-,14+/m1/s1
InChIKey
QVKPEMXUBULFBM-RISCZKNCSA-N
Chemical Structure
2D Structure
2D structure of Azd-5122
CAS: 1204707-71-0
CID: 44602493
Formula: C18H23F2N5O4S2
MW: 475.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight475.5
XLogP32.1
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count12
Rotatable Bond Count10
Exact Mass475.11595290
Monoisotopic Mass475.11595290
Topological Polar Surface Area161 Ų
Heavy Atom Count31
Formal Charge0
Complexity670
Isotope Atom Count0
Defined Atom Stereocenter Count2
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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Alternative Products

CatalogName
A3838-5SRT3109
A11097-100SRT3109 100mg
A11097-5SRT3109 5mg
A11097-50SRT3109 50mg
A11097-25SRT3109 25mg
A11097-10SRT3109 10mg
A11097-2SRT3109 2mg
A11097-10mM-DSRT3109 10mM * 1mL in DMSO

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