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SKLB1002

CAT: 0013-GTR19159750-01Size: 1 gDry Ice: NoHazardous: No
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CAT#:0013-GTR19159750-01Size:1 g
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
SKLB1002 is a new potent VEGFR2 inhibitor, which could significantly inhibit HUVEC proliferation, migration, invasion, and tube formation. Western blot analysis was conducted, which indicated that SKLB1002 inhibited VEGF-induced phosphorylation of VEGFR2 kinase and the downstream protein kinases including extracellular signal-regulated kinase, focal adhesion kinase, and Src. In vivo zebrafish model experiments showed that SKLB1002 remarkably blocked the formation of intersegmental vessels in zebrafish embryos. SKLB1002 inhibits angiogenesis and may be a potential drug candidate in anticancer therapy.
CAS Number
1225451-84-2
Product Name Alternative
SKLB1002 | SKLB 1002 | SKLB1002
Purity
>98% (HPLC)
Solubility
DMSO : 5.625 mg/mL 17.56 mM
Smiles
COc1c (OC) cc2c (Sc3nnc (C) s3) ncnc2c1
Molecular Formula
C13H12N4O2S2
Molecular Weight
320.39
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
2- ((6,7-dimethoxyquinazolin-4-yl) thio) -5-methyl-1,3,4-thiadiazole

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