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Fatostatin

CAT: 0013-GTR19160335-01Size: 1 gDry Ice: NoHazardous: No
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CAT#:0013-GTR19160335-01Size:1 g
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Description
Fatostatin ia an inhibitor of sterol regulatory element binding protein (SREBP) . It impairs the activation of SREBP-1 and SREBP-2. (In Vitro) :Fatostatin hydrobromide (125B11 hydrobromide) (0.1-1 μM; 3 days) inhibits the androgen-independent prostate cancer cell proliferation (IC50=0.1 μM) in an independent of the known IGF1-signaling pathway. Fatostatin hydrobromide inhibits insulin-induced adipogenesis of 3T3-L1 cells. (In Vivo) :Fatostatin hydrobromide (125B11 hydrobromide) (30 mg/kg; 150 mL; i.p.; daily for 28 days) reduces adiposity, ameliorates fatty liver by reducing triglyceride (TG) storage, and lowers hyperglycemia in ob/ob mice.
CAS Number
298197-04-3
Purity
>98% (HPLC)
Solubility
In Vitro: DMSO : 25 mg/mL (66.61 mM)
Smiles
Cc1ccc (cc1) c1csc (c2cc (CCC) ncc2) n1.Br
Molecular Formula
C18H18N2S·HBr
Molecular Weight
375.33
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.

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A9954-10Fatostatin
255283-01Fatostatin A

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