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Irisflorentin

CAT: 0013-GTR19159498-01Size: 100 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19159498-01Size:100 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Irisflorentin blocks apoptosis pathways, by exerting its effects by promoting rpn-3 expression to enhance the activity of proteasomes and down-regulating egl-1 expression. Irisflorentin has anti-inflammatory mechanism in LPS-activated RAW 264.7 macrophages, by reducing the transcriptional and translational levels of inducible nitric oxide synthase (iNOS) as well as the production of NO. (In Vitro) :Irisflorentin does not affect the LPS-stimulated RAW 264.7 macrophages viability up to a concentration of 40 μM.Irisflorentin (10-40 μM) inhibits the LPS-induced production of NO in a concentration-dependent manner without affecting the iNOS activity in RAW 264.7 macrophages.Irisflorentin (10-40 μM) concentration dependently inhibits the LPS (10 ng/mL) -induced increase in iNOS mRNA expression in LPS stimulated RAW 264.7 macrophages. Irisflorentin (10-40 μM) concentration-dependently suppresses the production of TNF-α, IL-1β and IL-6 in LPS stimulated RAW 264.7 macrophages.Irisflorentin (10-40 μM) concentration dependently inhibits the LPS (10 ng/mL) -induced increase in iNOS protein levels. Irisflorentin (10-40 μM) concentration-dependently suppresses LPS-induced p38 and ERK1/2 phosphorylation in a concentration-dependent manner, but slightly affects JNK phosphorylation.
CAS Number
41743-73-1
Purity
>98% (HPLC)
Solubility
In Vitro: DMSO : 50 mg/mL (129.42 mM)
Smiles
COC1=CC (=CC (=C1OC) OC) C2=COC3=CC4=C (C (=C3C2=O) OC) OCO4
Molecular Formula
C20H18O8
Molecular Weight
386.35
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.

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