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Cinobufagin

CAT: 0013-GTR19159456-01Size: 1 gDry Ice: NoHazardous: No
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CAT#:0013-GTR19159456-01Size:1 g
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Cinobufagin is a cardiotoxic bufanolide steroid secreted by the Asiatic toad Bufo gargarizans. It has similar effects to digitalis and is used in traditional Chinese medicine. Cinobufagin has been shown to have clinical applications in cancer treatment as well as immunomodulatory and analgesic properties. Cinobufagin induces apoptosis of osteosarcoma cells through inactivation of Notch signaling. Cinobufagin induces autophagy-mediated cell death in human osteosarcoma U2OS cells through the ROS/JNK/p38 signaling pathway.
CAS Number
470-37-1
Product Name Alternative
Cinobufagin | Cinobufagine | Cino-bufagin
Purity
>98% (HPLC)
Solubility
DMSO : ≥ 43 mg/mL; 97.17 mM
Smiles
CC (=O) O[C@@H]1[C@@H] ([C@]2 (CC[C@H]3[C@H] ([C@]42[C@@H]1O4) CC[C@H]1[C@@]3 (CC[C@@H] (C1) O) C) C) c1coc (=O) cc1
Molecular Formula
C26H34O6
Molecular Weight
442.55
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
(1R,2R,2aR,3aS,3bS,5aR,7S,9aS,9bR,11aS) -7-hydroxy-9a,11a-dimethyl-1- (2-oxo-2H-pyran-4-yl) hexadecahydronaphtho[1',2':6,7]indeno[1,7a-b]oxiren-2-yl acetate

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