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SB366791

CAT: 0013-GTR19159448-02Size: 500 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19159448-02Size:500 mg
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Description
SB-366791is a potent and selective TRPV1 antagonist. SB-366791 inhibits glutamatergic synaptic transmission in rat spinal dorsal horn following peripheral inflammation. SB-366791 decreased capsaicin-induced Ca2+ influx in cultured trigeminal ganglion cells in a concentration-dependent manner (0.5-10 microM) with an IC50 of 651.9 nM. SB366791 is a more selective and in vivo also a more potent TRPV1 receptor antagonist than capsazepine in the rat therefore, it may promote the assessment of the therapeutic utility of TRPV1 channel blockers.
CAS Number
472981-92-3
Product Name Alternative
SB-366791 | SB 366791 | SB366791
Purity
>98% (HPLC)
Solubility
DMSO : ≥ 39 mg/mL 135.54 mM; H2O : < 0.1 mg/mL
Smiles
COC1=CC=CC (=C1) NC (=O) /C=C/C2=CC=C (C=C2) Cl
Molecular Formula
C16H14ClNO2
Molecular Weight
287.74
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
3- (4-chlorophenyl) -N- (3-methoxyphenyl) -2-propenamide

Chemical Information

SB-366791

3-(4-chlorophenyl)-N-(3-methoxyphenyl)-2-propenamide is a secondary carboxamide and a member of cinnamamides.

CAS Number472981-92-3
PubChem CID667594
IUPAC Name(E)-3-(4-chlorophenyl)-N-(3-methoxyphenyl)prop-2-enamide
Molecular FormulaC16H14ClNO2
Molecular Weight287.74
XLogP4.2
Topological Polar Surface Area38.3
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count2
Rotatable Bond Count4
Heavy Atom Count20
Formal Charge0
Complexity337
SMILES
COC1=CC=CC(=C1)NC(=O)/C=C/C2=CC=C(C=C2)Cl
InChI
InChI=1S/C16H14ClNO2/c1-20-15-4-2-3-14(11-15)18-16(19)10-7-12-5-8-13(17)9-6-12/h2-11H,1H3,(H,18,19)/b10-7+
InChIKey
RYAMDQKWNKKFHD-JXMROGBWSA-N
Chemical Structure
2D Structure
2D structure of SB-366791
CAS: 472981-92-3
CID: 667594
Formula: C16H14ClNO2
MW: 287.74
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight287.74
XLogP34.2
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count2
Rotatable Bond Count4
Exact Mass287.0713064
Monoisotopic Mass287.0713064
Topological Polar Surface Area38.3 Ų
Heavy Atom Count20
Formal Charge0
Complexity337
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count1
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
MBS3608580-01SB366791
A15857-100SB366791 100mg
A15857-25SB366791 25mg
A15857-200SB366791 200mg
A15857-50SB366791 50mg
A15857-10SB366791 10mg
A15857-5SB366791 5mg
A15857-10mM-DSB366791 10mM * 1mL in DMSO
045273-01SB366791 (N- (3-Methoxyphenyl) -4-chlorocinnamide)
MBS6098510-01SB366791 (N-(3-Methoxyphenyl)-4-chlorocinnamide)

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