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Varenicline

CAT: 0013-GTR19159321-01Size: 200 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19159321-01Size:200 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Varenicline is a Selective α4β2 nicotinic acetylcholine receptor partial agonist. (In Vitro) :Varenicline (1 μM, 24 h) inhibits LPS-Induced cytokine secretions (IL-1β, IL-6, and TNF α) and cell proliferation rate in RAW 264.7 macrophages.Varenicline (250 nM) evokes action potentials (Aps) in the absence of ACh stimulation in Human adrenal chromaffin cells isolated from male and female organ donors.Varenicline (100 μM, 4 h) promotes migration of HUVECs by lowering the protein expression of VE-cadherin. (In Vivo) :Varenicline (Subcutaneous injection, 0.01-1 mg/kg, 3 days) given 10 min prior to nicotine (0.5 mg/kg, s.c.) inhibits nicotine conditioned place preference (CPP) .Varenicline (Subcutaneous injection, 2.5 mg/kg, 3 days) results in a place aversion which is dependent on α5 nAChRs but not β2 nAChRs.Varenicline (Subcutaneous injection, 0.1 and 0.5 mg/kg, 3 days) reverses nicotine withdrawal signs such as hyperalgesia and somatic signs and withdrawal-induced aversion in a dose-related manner.
CAS Number
866823-63-4
Field of Research
Pharmacology & Drug Discovery
Purity
>98% (HPLC)
Solubility
In Vitro: DMSO : 62.5 mg/mL (219.93 mM)
Smiles
Cl.Cl.c1c4c (cc2nccnc12) C3CC4CNC3
Molecular Formula
C13H15Cl2N3
Molecular Weight
284.18
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.

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B1140-100Varenicline
CS-O-34534Varenicline Impurity

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