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Buparvaquone

CAT: 0013-GTR19159291-01Size: 200 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19159291-01Size:200 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Buparvaquone is a hydroxynaphthoquinone antiprotozoal drug related to parvaquone and atovaquone. (In Vitro) :In 4-day proliferation assays, buparvaquone efficiently inhibits N. caninum tachyzoite replication (IC50=4.9 nM; IC100=100 nM) . Buparvaquone is significantly selective against L. (L.) infantum chagasi intracellular amastigotes, with an IC50 value of 1.5 μM. Other cutaneous species are also susceptible to buparvaquone, with IC50 values in the range 1-4 μM. (In Vivo) :Treatment of N. caninum infected mice with buparvaquone (100 mg/kg) either by intraperitoneal injection or gavage prevents neosporosis symptoms in 4 out of 6 mice in the intraperitoneally treated group, and in 6 out of 7 mice in the group receiving oral treatment. Both a hydrous gel and water-in-oil emulsion of buparvaquone significantly reduce cutaneous parasite burden and lesion size, compared with the untreated control.
CAS Number
88426-33-9
Purity
>98% (HPLC)
Solubility
DMSO : 33.33 mg/mL 102.10 mM
Smiles
CC (C) (C) C1CCC (CC2=C (O) C (=O) c3ccccc3C2=O) CC1
Molecular Formula
C21H26O3
Molecular Weight
326.44
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.

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