Flumatinib

CAT: 0013-GTR19159280-01Size: 500 mgDry Ice: NoHazardous: No

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CAT#:0013-GTR19159280-01Size:500 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

Flumatinib is an orally bioavailable tyrosine kinase inhibitor flumatinib, with potential antineoplastic activity. (In Vitro) :Flumatinib (HH-GV-678) can predominantly inhibit the autophosphorylation of Bcr-Abl in K562 cell. In higher concentration, Flumatinib can inhibit the phosphorylation of c-Kit in Mo7e cell and the phosphorylation of PDGFR in Swiss3T3 cell, however, Flumatinib has no or little effect on other tyrosine kinase including EGFR, KDR, c-Src and HER2 . Flumatinib (HHGV678) effectively overcame the drug resistance of certain KIT mutants with activation loop mutations (i.e., D820G, N822K, Y823D, and A829P) .

CAS Number

895519-90-1

Product Name Alternative

HHGV678

Purity

>98% (HPLC)

Solubility

DMSO : ≥ 32 mg/mL; 56.88 mM

Smiles

CC1=C (C=C (C=N1) NC (=O) C2=CC (=C (C=C2) CN3CCN (CC3) C) C (F) (F) F) NC4=NC=CC (=N4) C5=CN=CC=C5

Molecular Formula

C29H29F3N8O

Molecular Weight

562.6

Storage Conditions

Storage temperature: -20°C. Stability: ≥ 2 years

Notes

For research use only.

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Catalog	Name
BA8803-5	Flumatinib
A8691-10	Flumatinib mesylate
HY-13905-01	Flumatinib (mesylate)
A16258-10	Flumatinib 10mg
A16258-100	Flumatinib 100mg
A16258-50	Flumatinib 50mg
A16258-25	Flumatinib 25mg
A16258-1	Flumatinib 1mg
AR-F10295-01	Flumatinib-d3
A16258-5	Flumatinib 5mg

Flumatinib

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