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ML365

CAT: 0013-GTR19159238-01Size: 200 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19159238-01Size:200 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
ML365 is a potent and selective K2P3.1 TASK-1 channel blocker. ML365 blocks TASK1 channels in both the thallium influx fluorescent assay (IC50 = 4 nM) and an automated electrophysiology assay (IC50 = 16 nM) . Based on potency differences, it possesses more than 60-fold selectivity for inhibition of TASK1 over a closely-related, two-pore domain potassium channel, TASK3. ML365 displays little or no inhibition at 30 μM of more distantly related potassium channels, Kir2.1, potassium voltage-gated channel, KQT-like subfamily, member 2 (KCNQ2), and human ether-a go-go-related gene (hERG) . Based on these criteria, ML365 is a best-in-class probe and is a useful pharmacological probe for in vitro studies of TASK1 function and in further studies aimed at developing therapeutic intervention.
CAS Number
947914-18-3
Product Name Alternative
ML365 | ML-365 | ML 365
Purity
>98% (HPLC)
Solubility
DMSO : ≥ 100 mg/mL 277.46 mM H2O : < 0.1 mg/mL
Smiles
COc1ccccc1C (=O) Nc1cccc (NC (=O) c2cccc (C) c2) c1
Molecular Formula
C22H20N2O3
Molecular Weight
360.41
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
2-Methoxy-N-[3-[ (3-methylbenzoyl) amino]phenyl]benzamide

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