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Berbamine

CAT: 0013-GTR19159211-01Size: 200 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19159211-01Size:200 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Berbamine has high binding affinity toward the (GGA) ; G-quadruplex. Berbamine and its derivatives are promising agents to suppress liver cancer growth by targeting CAMKII. Berbamine may be the first ATP-competitive inhibitor of CaMKII γ, could be as a new type of molecular targeted agent through inhibition of the CaMKII γ activity for treatment of leukemia. 4. Berbamine can enhance the antitumor activity of gemcitabine by inhibiting cell growth and inducing apoptosis, possibly through the regulation of the expression of apoptosis-related proteins and the activation of TGF-β/Smad signaling pathway. Berbamine confers cardioprotection against I/R injury by attenuating [Ca (2+) inf (i) overloading and preventing calpain activation through the activation of the PI3K-Akt-GSK3β pathway and, subsequently, opening of the mitoK (ATP) channel.
CAS Number
478-61-5
Purity
>98% (HPLC)
Solubility
In Vitro: DMSO : 100 mg/mL (164.28 mM)
Smiles
CN1CCC2=CC (=C3C=C2C1CC4=CC=C (C=C4) OC5=C (C=CC (=C5) CC6C7=C (O3) C (=C (C=C7CCN6C) OC) OC) O) OC
Molecular Formula
C37H40N2O6
Molecular Weight
608.73
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.

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