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Gelsemine

CAT: 0013-GTR19159138-01Size: 100 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19159138-01Size:100 mg
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Description
Gelsemine has antitumor activity. Gelsemine has anti-oxidative activity. Gelsemine has anti-hyperlipidemic activity. Gelsemine has marked antinociception in inflammatory, neuropathic and bone cancer pains without inducing antinociceptive tolerance. (In Vivo) :Gelsemine is an effective agent for treatment of both neuropathic pain and sleep disturbance in partial sciatic nerve ligation (PSNL) mice. Gelsemine (4 mg/kg) exerts analgesic effects on PSNL-induced mechanical allodynia and thermal hyperalgesia. In PSNL mice, Gelsemine (2 and 4 mg/kg) increases the mechanical threshold for 4 h and prolonged the thermal latencies for 3 h. Furthermore, Gelsemine (4 mg/kg, administered at 6:30 AM) increases non-rapid eye movement (non-REM, NREM) sleep, decreases wakefulness, but does not affect rapid eye movement (REM) sleep during the first 3 h in PSNL mice.Immunohistochemical study shows that PSNL increases c-Fos expression in the neurons of the anterior cingulate cortex, and Gelsemine (4 mg/kg) decreases c-Fos expression by 58%.
CAS Number
509-15-9
Purity
>98% (HPLC)
Solubility
In Vitro: DMSO : 100 mg/mL (310.17 mM)
Smiles
CN1CC2 (C3CC4C5 (C2C1C3CO4) C6=CC=CC=C6NC5=O) C=C
Molecular Formula
C20H22N2O2
Molecular Weight
322.4
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.

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