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Estramustine phosphate sodium

CAT: 0013-GTR19159109-01Size: 200 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19159109-01Size:200 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Estramustine phosphate sodium is an antimicrotubule chemotherapy agent; arrests prostate cancer cells in the G2/M phase of the cell cycle. (In Vitro) :Estramustine phosphate sodium (1 μg/ mL, 48 h) suppresses PC3 cell growth.Estramustine phosphate sodium (2 μg/mL, 48 h) elevates phosphatidylserine eversion amount on PC3 cells and induces PC3 cell apoptosis through reducing miR-31.Estramustine phosphate sodium (0-40 μM, 24-72 h) inhibits cell proliferation and tubulin cytoskeleton in RAW 264.7 cells.Estramustine phosphate sodium (10 μM, 24 h) inhibits TGF-β-induced RAW 264.7 cell migration, as well as TGF-β-induced uPA production by inhibiting Smad3 activation. (In Vivo) :Estramustine phosphate sodium (Intraperitoneal injection, 4 or 12 mg/kg, a daily dose for 2 weeks) inhibits PAC120 tumor growth 53% by day 35.
CAS Number
52205-73-9
Field of Research
Pharmacology & Drug Discovery
Purity
>98% (HPLC)
Solubility
H2O : 62.5 mg/mL 110.75 mM; DMSO : 5 mg/mL 8.86 mM
Smiles
[Na+].[Na+].ClCCN (CCCl) C (=O) Oc3cc4CC[C@@H]1[C@H] (CC[C@]2 (C) [C@H] (CC[C@@H]12) OP ([O-]) ([O-]) =O) c4cc3
Molecular Formula
C23H30Cl2NNa2O6P
Molecular Weight
564.35
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.

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