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Prunetin

CAT: 0013-GTR19159033-01Size: 100 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19159033-01Size:100 mg
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Description
Prunetin significantly reduces serum levels of inflammatory cytokines and mortality in mice challenged with lipopolysaccharide. Prunetin mediates anti-obesity/adipogenesis effects by suppressing obesity-related transcription through a feedback mechanism that regulates the expression of adiponectin, adipoR1, adipoR2, and AMPK. Prunetin and biochanin A are potent reducers of NF-κB and ERK activation, zonula occludens 1 tyrosine phosphorylation, and metalloproteinase-mediated shedding activity, which may account for the barrier-improving ability of these isoflavones. Prunetin significantly suppresses ATP-induced mucin secretion from cultured RTSE cells; Prunetin inhibits the production of MUC5AC mucin protein induced by EGF or PMA from NCI-H292 cells; Prunetin also inhibits the expression of MUC5AC mucin gene induced by EGF or PMA from NCI-H292 cells.
CAS Number
552-59-0
Purity
>98% (HPLC)
Solubility
In Vitro: DMSO : 100 mg/mL (351.79 mM)
Smiles
COC1=CC (=C2C (=C1) OC=C (C2=O) C3=CC=C (C=C3) O) O
Molecular Formula
C16H12O5
Molecular Weight
284.26
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.

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