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Leuprorelin

CAT: 0013-GTR19158855-01Size: 100 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19158855-01Size:100 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Leuprolide is an agonist at pituitary GnRH receptors.GnRH receptor Leuprorelin is a gonadotrophin-releasing hormone (GnRH) analogue used to treat a wide range of sex hormone-related disorders including advanced prostatic cancer endometriosis and precocious puberty. Leuprorelin acts primarily on the anterior pituitary inducing a transient early rise in gonadotrophin release. With continued use Leuprorelin causes pituitary desensitisation and/or down-regulation leading to suppressed circulating levels of gonadotrophins and sex hormones.By interrupting the normal pulsatile stimulation of and thus desensitizing the GnRH receptors it indirectly downregulates the secretion of gonadotropins luteinizing hormone (LH) and follicle-stimulating hormone (FSH) leading to hypogonadism and thus a dramatic reduction in estradiol and testosterone levels in both sexes.
CAS Number
53714-56-0
Product Name Alternative
Leuprolide
Purity
>98% (HPLC)
Solubility
DMSO:10 mM; Water:1mg/mL
Smiles
CCNC (=O) [C@@H]1CCCN1C (=O) [C@H] (CCCNC (N) =N) NC (=O) [C@H] (CC (C) C) NC (=O) [C@@H] (CC (C) C) NC (=O) [C@H] (Cc1ccc (O) cc1) NC (=O) [C@H] (CO) NC (=O) [C@H] (Cc1c[nH]c2ccccc12) NC (=O) [C@H] (Cc1cnc[nH]1) NC (=O) [C@@H]1CCC (=O) N1
Molecular Formula
C59H84N16O12
Molecular Weight
1209.4
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
(S) -N-ethyl-1- (((S) -5-oxopyrrolidine-2-carbonyl) -L-histidyl-L-tryptophyl-L-seryl-L-tyrosyl-D-leucyl-L-leucyl-L-arginyl) pyrrolidine-2-carboxamide

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