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Licochalcone B

CAT: 0013-GTR19158755-02Size: 500 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19158755-02Size:500 mg
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Description
Licochalcone B (LCB) inhibits the proliferation of human malignant bladder cancer cell lines (T24 and EJ) in vitro and antitumor activity in vivo in MB49 (murine bladder cancer cell line) tumor model. LCB and Licochalcone D (LCD) significantly reduced the LPS-induced production of NO, TNFalpha and MCP-1. A novel LCB derivative compound: (E) -3- (3, 4-dihydroxy-2-methoxyphenyl) -1- (2, 4-dihydroxyphenyl) prop-2-en-1-one inhibits inflammatory reactions in macrophages and protects mice from endotoxin shock.
CAS Number
58749-23-8
Product Name Alternative
Licochalcone B | Licochalcone-B
Purity
>98% (HPLC)
Solubility
In Vitro: DMSO : 83.33 mg/mL (291.08 mM)
Smiles
COC1=C (C=CC (=C1O) O) C=CC (=O) C2=CC=C (C=C2) O
Molecular Formula
C16H14O5
Molecular Weight
286.28
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
(E) -1- (3,4-dihydroxy-2-methoxyphenyl) -3- (4-hydroxyphenyl) prop-2-en-1-one

Chemical Information

Licochalcone B

Licochalcone B is a member of chalcones.

CAS Number58749-23-8
PubChem CID5318999
IUPAC Name(E)-3-(3,4-dihydroxy-2-methoxyphenyl)-1-(4-hydroxyphenyl)prop-2-en-1-one
Molecular FormulaC16H14O5
Molecular Weight286.28
XLogP2.6
Topological Polar Surface Area87
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count5
Rotatable Bond Count4
Heavy Atom Count21
Formal Charge0
Complexity373
SMILES
COC1=C(C=CC(=C1O)O)/C=C/C(=O)C2=CC=C(C=C2)O
InChI
InChI=1S/C16H14O5/c1-21-16-11(5-9-14(19)15(16)20)4-8-13(18)10-2-6-12(17)7-3-10/h2-9,17,19-20H,1H3/b8-4+
InChIKey
DRDRYGIIYOPBBZ-XBXARRHUSA-N
Chemical Structure
2D Structure
2D structure of Licochalcone B
CAS: 58749-23-8
CID: 5318999
Formula: C16H14O5
MW: 286.28
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight286.28
XLogP32.6
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count5
Rotatable Bond Count4
Exact Mass286.08412354
Monoisotopic Mass286.08412354
Topological Polar Surface Area87 Ų
Heavy Atom Count21
Formal Charge0
Complexity373
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count1
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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