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Gabapentin HCl

CAT: 0013-GTR19158737-01Size: 1 gDry Ice: NoHazardous: No
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CAT#:0013-GTR19158737-01Size:1 g
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Description
Gabapentin HCl is a GABA analogue, used to treat seizures and neuropathic pain. (In Vitro) :Gabapentin (0-300 μM) hydrochloride produces a concentration-dependent inhibition of the K+-induced [Ca2+]i increase in synaptosomes (IC50=14 μM; maximal inhibition by 36%) . Gabapentin (100 μM) hydrochloride decreases the K+-evoked release of endogenous aspartate and glutamate in neocortical slices by 16 and 18%, respectively. Gabapentin (0-1000 μM) hydrochloride reduces the K+-evoked [3H]-noradrenaline release in neocortical slices (IC50=48 μM; maximal inhibition of 46%) but not from synaptosomes. (In Vivo) :Gabapentin (5 and 10 mg/kg; i.p.; once; male BALB/c mice) hydrochloride has improving effects on spatial and emotional cognitive performance of naive mice in Morris water maze (MWM), passive avoidance (PA) and modified elevated plus maze (mEPM) tasks.Gabapentin (1-100 mg/kg; i.p.; once; male mice) hydrochloride has analgesic effect and reduces writhing in a dose-dependent manner.
CAS Number
60142-95-2
Field of Research
Pharmacology & Drug Discovery
Purity
>98% (HPLC)
Solubility
H2O : 50 mg/mL 240.73 mM
Smiles
Cl.NCC1 (CC (O) =O) CCCCC1
Molecular Formula
C9H17NO2·HCl
Molecular Weight
207.7
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.

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