Schizandrin A

Schizandrin A, also known as Deoxyschizandrin, is a bio-active isolate of Schisandra chinensis. Schizandrin A protects against cerebral ischemia-reperfusion injury by suppressing inflammation and oxidative stress and regulating the AMPK/Nrf2 pathway regulation. Schisandrin A prevents oxidative stress-induced DNA damage and apoptosis by attenuating ROS generation in C2C12 cells. (In Vitro) :Schisandrin A (Sch A) strongly inhibits microsomal midazolam 1-hydroxylation catalyzed by CYP3A, with an IC50 of 6.60 μM. The recovery of enzyme activity in the absence or presence of Schisandrin A is shown in dilution assay plots. The Ki value for Schisandrin A is obtained from the Dixon plots and is 5.83 μM. The inactivation of rat liver microsomal midazolam 1-hydroxylation activity by Schisandrin A in the presence of NADPH is found to be time- and concentration-dependent. The Kinact and Ki are estimated to be 0.134/min and 4.51 μM, respectively for Schisandrin A. (In Vivo) :Schisandrin A (SchA) significantly inhibits CYP3A activity in rat hepatic microsomes and Vmax value of each group in a concentration-dependent manner. The double-reciprocal plots and the secondary plot show that Schisandrin A inhibits CYP3A activity, with an apparent Ki value of 30.67 mg/kg. In each Schisandrin A-treated group, Schisandrin A also significantly decreases 1-hydroxymidazolam plasma concentrations compared with the negative group (to levels similar to the positive group) .

61281-38-7

Deoxyschisandrin | Deoxyschizandrin | Schizandrin A

>98% (HPLC)

DMSO : 50 mg/mL 120.05 mM; H2O : < 0.1 mg/mL

C[C@@H]1Cc2cc (c (c (c2c2c (c (c (cc2C[C@@H]1C) OC) OC) OC) OC) OC) OC

C24H32O6

416.51

Storage temperature: -20°C. Stability: ≥ 2 years

For research use only.