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Praeruptorin A (b)

CAT: 0013-GTR19158573-01Size: 200 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19158573-01Size:200 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Praeruptorin A could exhibit its anti-osteoclastogenic activity by inhibiting p38/Akt-c-Fos-NFATc1 signaling and PLCγ-independent Ca (2+) oscillation Praeruptorin A has the potential to inhibit migration/fusion of preosteoclasts in vitro and bone erosion in vivo by targeting calmodulin and inhibiting the Ca (2+) /calmodulin-CaMKIV-CREB-NFATc1 and/or Ca (2+) /calmodulin-calcineurin-NFATc1 signaling axis. Praeruptorin A and praeruptorin C can significantly upregulate multidrug resistance-associated protein 2 expression via the constitutive androstane receptor-mediated pathway in vitro, and this should be taken as an herb-drug interaction.
CAS Number
73069-25-7
Purity
>98% (HPLC)
Solubility
In Vitro: DMSO : 100 mg/mL (258.80 mM)
Smiles
CC=C (C) C (=O) OC1C (C2=C (C=CC3=C2OC (=O) C=C3) OC1 (C) C) OC (=O) C
Molecular Formula
C21H22O7
Molecular Weight
386.4
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.

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