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SB 297006

CAT: 0013-GTR19159035-01Size: 200 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19159035-01Size:200 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
SB 297006 is an antagonist of C-C chemokine receptor 3 (CCR3; IC50 = 39 nM), which normally is activated by eotaxin, eotaxin-3, MCP-3, MCP-4, RANTES, and MIP-1δ. It is at least 250-fold selective for CCR3 over a panel of other chemokine receptors. SB 297006 blocks CCR3-mediated calcium mobilization induced by eotaxin, eotaxin-2, and MCP-4 in transfected cells. It suppresses antigen-induced accumulation of Th2 lymphocytes and eosinophils in lungs of mice when delivered subcutaneously (100 mg/kg) .
CAS Number
58816-69-6
Purity
>98% (HPLC)
Solubility
DMSO : 150 mg/mL 438.15 mM; H2O : < 0.1 mg/mL
Smiles
O=[N+] ([O-]) c2ccc (C[C@H] (NC (=O) c1ccccc1) C (=O) OCC) cc2
Molecular Formula
C18H18N2O5
Molecular Weight
342.4
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.

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