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Alofanib

CAT: 0013-GTR19158429-01Size: 200 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19158429-01Size:200 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Alofanib is a selective allosteric inhibitor of FGFR2 and has a dramatic inhibitory effect on FGF2-induced phosphorylation of FRS2a in KATO III cells (IC50 <10 nM) . It has no direct effect on FGF2-dependent FGFR1 and FGFR3 phosphorylation levels in either cell lines and no effects on FGF2-FGFR2 binding. (In Vitro) :Alofanib inhibits phosphorylation of FRS2α with IC50s of 7 and 9 nM in hFOB and SUM 52PE cells expressing different FGFR2 isoforms.Alofanib (0.2-0.8 μM, 6 hours) inhibits FGF-mediated proliferation in a panel of four cell lines representing several tumour types (triple-negative breast cancer, melanoma, and ovarian cancer) with GI50s of 16-370 nM. (In Vivo) :In a FGFR-driven human tumour xenograft model, oral administration of alofanib (30 mg/kg, gavage, daily, 40 days, N=10) is well tolerated and results in potent antitumour activity.Treatment with alofanib (10 mg/kg/d, 0, 3 and 6 d, intraperitoneally) ablates experimental FGF-induced angiogenesis in vivo.
CAS Number
1612888-66-0
Product Name Alternative
RPT835
Purity
>98% (HPLC)
Solubility
DMSO: 50 mg/mL; Water: Insoluble
Smiles
Cc1cc (c (NS (=O) (=O) c2cccc (c2) C (O) =O) cc1-c1cccnc1) [N+] ([O-]) =O
Molecular Formula
C19H15N3O6S
Molecular Weight
413.4
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
3- (N- (4-methyl-2-nitro-5- (pyridin-3-yl) phenyl) sulfamoyl) benzoic acid

Alternative Products

CatalogName
BA2864-100Alofanib
MBS386079-01Alofanib (RPT835)

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