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TGN020

CAT: 0013-GTR19158411-01Size: 200 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19158411-01Size:200 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
TGN-020 is an inhibitor of Aquaporin 4 (AQP4 IC50: 3.1 μM) the most abundant water channel in the brain. (In Vitro) :PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. (In Vivo) :TGN-020 (0.02 mg/μL; two microliter intravitreal injections) can suppress retinal edema in STZ-induced diabetic rats (nine-week-old male Wistar rats) retinas.TGN-020 (100 mg/kg; ip; single dose immediately followed SCI) promotes functional recovery at days 3, 7, 14, 21, and 28, as well as reduces the degree of edema and inhibits the expression of AQP4, GFAP, PCNA at days 3 after SCI. TGN-020 inhibits the glial scar formation and upregulates GAP-43 expression in adult female Sprague-Dawley rats (180-220 g, 9-10 weeks old) with SCI.
CAS Number
51987-99-6
Purity
>98% (HPLC)
Solubility
DMSO: 8 mg/mL
Smiles
O=C (Nc1nncs1) c1cccnc1
Molecular Formula
C8H6N4OS
Molecular Weight
206.22
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
N-134-Thiadiazol-2-yl-3-pyridinecarboxamide

Alternative Products

CatalogName
C07038-5mgTGN020

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