Products for Research Use Only
RegisterLogin

Theaflavin 33'-digallate

CAT: 0013-GTR19158198-01Size: 200 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0013-GTR19158198-01Size:200 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
8-Gingerol (TFDG) a major polyphenol found in black tea is an inducer of oxidative stress which has anti-inflammatory and cancer chemopreventive actions it reduces tumor angiogenesis by downregulating HIF-1αand VEGF. (In Vitro) :Theaflavin 3,3'-digallate (TF-3; 6.25, 12.5, 25 μM; 24 hours) markedly reduces viral RNA copy numbers and NS3, U87 MG protein expression in a dose-dependent manner.Theaflavin 3,3'-digallate inhibits dose-dependently ZIKV replication in Vero E6 cells (EC50=7.65 μM) . Theaflavin 3,3'-digallate has minor cytotoxicity up to 40 μM in Vero E6 cells. Theaflavin 3,3'-digallate can inhibit the post-entry events of the ZIKV replication cycle from gene transcription and translation levels.Theaflavin 3,3'-digallate is generally regarded as the effective component for the inhibitory effects against carcinogenesis without adverse side effects by affecting multiple signal transduction pathways, such as upregulating p53 and p21, inhibiting phosphorylation of the cell survival protein Akt and MAPK pathway, downregulation of NF-κB, shifting the ratio between pro-/antiapoptotic proteins. Theaflavin 3,3'-digallate causes a rapid and sustained decrease in phospho-ERK1/2 and -MEK1/2 protein expression. Theaflavin 3,3'-digallate inhibits HCT116 cell growth with an IC50 of 17.26 μM.
CAS Number
30462-35-2
Product Name Alternative
8-Gingerol | TFDG
Purity
>98% (HPLC)
Solubility
DMSO: 10 mg/mL (11.51 mM) ; Ethanol: 10 mg/mL
Smiles
Oc1cc (O) c2C[C@@H] (OC (=O) c3cc (O) c (O) c (O) c3) [C@H] (Oc2c1) c1cc (O) c (O) c2c1cc (cc (O) c2=O) [C@H]1Oc2cc (O) cc (O) c2C[C@H]1OC (=O) c1cc (O) c (O) c (O) c1
Molecular Formula
C43H32O20
Molecular Weight
868.7
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.

Related Products

CatalogName
GTR19169360-01Theaflavin digallate
GTR19169739-01Theaflavin 3,3′-digallate
GTR19159891-01Theaflavine-3,3'-digallate
GTR19166452-01Theaflavin
GTR19153884Theaflavin
GTR19154433Theaflavin-3-gallate
GTR19188398-01Theaflavin-3'-Gallate
GTR19159301-01Theaflavin-3'-Gallate
GTR19171513-01Theaflavin-3-gallate
GTR19158006-01Theaflavin-3-gallate

Alternative Products

CatalogName
MBS3610137-01Theaflavin 33'-digallate
T4S0554-01Theaflavin digallate
E0066-5mgTheaflavin 3,3'-digallate
301051Theaflavin digallate (Theaflavine-3,3'-digallate)
FT65480-01Theaflavin-3,3'-digallate
T5429-01Theaflavin 3,3′-digallate
HY-N1992R-01Theaflavin 3,3'-digallate (Standard)
AB2560Theaflavin 3,3'-digallate (TFDG)
M20777-01Theaflavin

Popular Products