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SIB-1757

CAT: 0013-GTR19157921-01Size: 1 gDry Ice: NoHazardous: No
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CAT#:0013-GTR19157921-01Size:1 g
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
SIB-1757 is a selective antagonist of mGlu5 metabotropic glutamate receptor subtype (hmGlu5, IC50 : 0.4 μM) .SIB-1757 was given by either intrathecal (i.th.), subcutaneous (s.c.) or intraplantar (i.pl.) injection. In SNL rats, i.th. SIB-1757 produced a partial reversal of tactile allodynia with a shallow dose-response curve ranging over three-orders of magnitude; SIB-1757 was inactive against allodynia when given systemically. SIB-1757 produced full reversal of thermal hyperalgesia in SNL rats following administration either spinally or locally to the injured paw; administration to the contralateral paw had no effect. SIB-1757 did not produce antinociception in either the SNL or sham-operated rats by any route.
CAS Number
31993-01-8
Product Name Alternative
6-methyl-2-[ (E) -phenyldiazenyl]pyridin-3
Purity
>98% (HPLC)
Solubility
DMSO:17 mg/ml (79.72 mM)
Smiles
Cc1ccc (O) c (n1) \N=N\c1ccccc1
Molecular Formula
C12H11N3O
Molecular Weight
213.24
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.

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