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TCN213

CAT: 0013-GTR19157918-01Size: 200 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19157918-01Size:200 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
TCN213 is an antagonist of NMDA receptor that has a selective for NR1/NR2A over NR1/NR2BTCN 213 antagonism of GluN1/GluN2A NMDA receptors was dependent on glycine but independent of glutamate concentrations in external recording solutions. Antagonism by TCN 213 was surmountable and gave a Schild plot with unity slope. TCN 213 block of GluN1/GluN2B NMDA receptor-mediated currents was negligible. In cortical neurones, at a early developmental stage predominantly expressing GluN2B-containing NMDA receptors, TCN 213 failed to antagonize NMDA receptor-mediated currents or to prevent GluN2B-dependent, NMDA-induced excitoxicity. In older cultures (DIV 14) or in neurones transfected with GluN2A subunits, TCN 213 antagonized NMDA-evoked currents. Block by TCN 213 of NMDA currents inversely correlated with block by ifenprodil, a selective GluN2B antagonist.
CAS Number
556803-08-8
Purity
>98% (HPLC)
Solubility
In Vitro: DMSO : 250 mg/mL (663.94 mM)
Smiles
O=C (CSc1nnc (NCc2ccccc2) s1) NCC1CCCCC1
Molecular Formula
C18H24N4OS2
Molecular Weight
376.54
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.

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