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Duloxetine

CAT: 0013-GTR19157912-01Size: 100 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19157912-01Size:100 mg
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Description
Duloxetine is an inhibitor of serotonin-norepinephrine reuptake (Ki of 4.6 nM), with treatment of major depressive disorder and generalized anxiety disorder.IC50 of duloxetine for the resting and inactivated wild-type hNav1.7 Na+ channel were 22.1+/-0.4 and 1.79+/-0.10 microM, respectively (mean+/-SE, n=5) . The IC50 for the open Na+ channel was 0.25+/-0.02 microM (n=5), as determined by the block of persistent late Nav1.7 Na+ currents. Similar open-channel block by duloxetine was found in the muscle Nav1.4 isoform (IC50=0.51+/-0.05 microM; n=5) . Block by duloxetine appeared via the conserved local anesthetic receptor as determined by site-directed mutagenesis. Finally, duloxetine elicited strong use-dependent block of neuronal transient Nav1.7 Na+ currents during repetitive stimulations.
CAS Number
116539-59-4
Field of Research
Pharmacology & Drug Discovery
Purity
>98% (HPLC)
Smiles
CNCC[C@H] (Oc1cccc2ccccc12) c1cccs1
Molecular Formula
C18H19NOS
Molecular Weight
297.42
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.

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