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SC-26196

CAT: 0013-GTR19157896-02Size: 500 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19157896-02Size:500 mg
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Description
SC-26196 is an orally active inhibitor of Delta6 desaturase (D6D) with IC50 of 0.2 μM in a rat liver microsomal assay, with antiinflammatory properties. The FADS2 inhibitor SC26196 reduced PBMC, but not Jurkat cell, proliferation suggesting PUFA synthesis is involved in regulating mitosis in PBMCs.
CAS Number
218136-59-5
Purity
>98% (HPLC)
Solubility
DMSO:4mg/ml (9.44 Mm; Need ultrasonic)
Smiles
C1CN (CCN1CCCC (C#N) (C2=CC=CC=C2) C3=CC=CC=C3) N=CC4=CN=CC=C4
Molecular Formula
C27H29N5
Molecular Weight
423.55
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.

Chemical Information

(E)-2,2-Diphenyl-5-(4-((pyridin-3-ylmethylene)amino)piperazin-1-yl)pentanenitrile

SC-26196 is sC 26196 is a selective FADS2 (Delta6 desaturase) inhibitor that displays selectivity over Delta5 and Delta9 desaturases. It completely blocks the conversion of linoleic acid to arachidonic acid (AA). It also blocks aging-related increases in AA in myocardial cardiolipin in mice, attenuating contractile dysfunction without impacting mitochondrial oxidative stress.

CAS Number218136-59-5
PubChem CID9845201
IUPAC Name2,2-diphenyl-5-[4-[(E)-pyridin-3-ylmethylideneamino]piperazin-1-yl]pentanenitrile
Molecular FormulaC27H29N5
Molecular Weight423.6
XLogP4.4
Topological Polar Surface Area55.5
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count5
Rotatable Bond Count8
Heavy Atom Count32
Formal Charge0
Complexity599
SMILES
C1CN(CCN1CCCC(C#N)(C2=CC=CC=C2)C3=CC=CC=C3)/N=C/C4=CN=CC=C4
InChI
InChI=1S/C27H29N5/c28-23-27(25-10-3-1-4-11-25,26-12-5-2-6-13-26)14-8-16-31-17-19-32(20-18-31)30-22-24-9-7-15-29-21-24/h1-7,9-13,15,21-22H,8,14,16-20H2/b30-22+
InChIKey
QFYKXKMYVYOUNJ-JBASAIQMSA-N
Chemical Structure
2D Structure
2D structure of (E)-2,2-Diphenyl-5-(4-((pyridin-3-ylmethylene)amino)piperazin-1-yl)pentanenitrile
CAS: 218136-59-5
CID: 9845201
Formula: C27H29N5
MW: 423.6
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight423.6
XLogP34.4
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count5
Rotatable Bond Count8
Exact Mass423.24229595
Monoisotopic Mass423.24229595
Topological Polar Surface Area55.5 Ų
Heavy Atom Count32
Formal Charge0
Complexity599
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count1
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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