RABBIT ANTI VPS34

• NCBI Gene ID:

  225326

• Reactivity:

  Mouse, Rat

• Storage Conditions:

  Store at 4 °C or at -20 °C if preferred. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
  Shelf Life: 18 months from date of despatch.

• Specificity:

  This item specifically recognises VPS34 (vacuolar protein sorting 34), otherwise known as PI3-kinase type 3 (PIK3C3), a ubiquitously expressed class III PI3K (phosphoinositide 3-kinase), and member of the PI3/PI4-kinase family, which specifically utilizes phosphatidylinositol (PtdIn) as a substrate, and functions as the catalytic subunit of the PI3K complex.
  VPS34 plays a role in the transport of lysosomal enzyme precursors to lysosomes, and in endocytosis and vesicular trafficking, and has been strongly implicated as a regulator of autophagy, forming a multi-protein complex with the proautophagic tumor suppressors Beclin1/Atg6, Bif-1, and UVRAG, in the initiation of autophagosome formation. Distinct complexes of VPS34 have been shown to regulate endocytic processes vital for late-stage autophagosome-lysosome fusion.
  This item has been tested in immunofluorescence using HUVEC cells, in conjunction with Hoescht 33342 (blue) nuclear staining.

• Other Gene Names:

  [Pik3c3; Pik3c3; Vps34; 5330434F23Rik; PI3-kinase type 3; PI3K type 3; PtdIns-3-kinase type 3]

• Short Name:

  [VPS34]

• Other Product Names:

  [phosphatidylinositol 3-kinase catalytic subunit type 3; Phosphatidylinositol 3-kinase catalytic subunit type 3; phosphatidylinositol 3-kinase catalytic subunit type 3; PI3-kinase type 3; PI3K type 3; ptdIns-3-kinase type 3; phosphoinositide-3-kinase, class 3; Phosphoinositide-3-kinase class 3]

• NCBI GI Number:

  42475974

• NCBI Accession Number:

  NP_852079.2

• NCBI GB Accession Number:

  NM_181414.5

• CAS Number:

  9007-83-4