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RABBIT ANTI VPS34

CAT: 0544-MBS224363-01Size: 0.1 mgDry Ice: NoHazardous: No
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CAT#:0544-MBS224363-01Size:0.1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
9007-83-4
NCBI Gene ID
225326
Reactivity
Mouse, Rat
Storage Conditions
Store at 4 °C or at -20 °C if preferred. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life: 18 months from date of despatch.
Specificity
This item specifically recognises VPS34 (vacuolar protein sorting 34), otherwise known as PI3-kinase type 3 (PIK3C3), a ubiquitously expressed class III PI3K (phosphoinositide 3-kinase), and member of the PI3/PI4-kinase family, which specifically utilizes phosphatidylinositol (PtdIn) as a substrate, and functions as the catalytic subunit of the PI3K complex.
VPS34 plays a role in the transport of lysosomal enzyme precursors to lysosomes, and in endocytosis and vesicular trafficking, and has been strongly implicated as a regulator of autophagy, forming a multi-protein complex with the proautophagic tumor suppressors Beclin1/Atg6, Bif-1, and UVRAG, in the initiation of autophagosome formation. Distinct complexes of VPS34 have been shown to regulate endocytic processes vital for late-stage autophagosome-lysosome fusion.
This item has been tested in immunofluorescence using HUVEC cells, in conjunction with Hoescht 33342 (blue) nuclear staining.
Other Gene Names
[Pik3c3; Pik3c3; Vps34; 5330434F23Rik; PI3-kinase type 3; PI3K type 3; PtdIns-3-kinase type 3]
Short Name
[VPS34]
Other Product Names
[phosphatidylinositol 3-kinase catalytic subunit type 3; Phosphatidylinositol 3-kinase catalytic subunit type 3; phosphatidylinositol 3-kinase catalytic subunit type 3; PI3-kinase type 3; PI3K type 3; ptdIns-3-kinase type 3; phosphoinositide-3-kinase, class 3; Phosphoinositide-3-kinase class 3]
NCBI GI Number
42475974
NCBI Accession Number
NP_852079.2
NCBI GB Accession Number
NM_181414.5