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GSK3145095

CAT: 0013-GTR19157894-01Size: 200 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19157894-01Size:200 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
GSK3145095 is an orally active inhibitor of RIPK1 with IC50 of 5 nM, with potential immunomodulatory activities and antineoplastic. GSK3145095 potently binds to RIP1 with exquisite kinase specificity and has excellent activity in blocking RIP1 kinase-dependent cellular responses. Highlighting its potential as a novel cancer therapy, the inhibitor was also able to promote a tumor suppressive T cell phenotype in pancreatic adenocarcinoma organ cultures. (In Vitro) :GSK3145095 potently blocks the TNF response as shown by determination of overall cell viability as measured by cellular ATP levels (IC50 = 1.6 nM), cell death as measured by LDH release (IC50 = 0.5 nM) and RIP1-dependent inflammatory cytokine MIP-1β production, either as absolute levels for protein, or fold changes in mRNA expression (IC50 = 0.4 nM) .
CAS Number
1622849-43-7
Purity
>98% (HPLC)
Solubility
DMSO:245mg/ml (616.54 Mm; Need ultrasonic)
Smiles
FC1=CC2=C (NC (=O) [C@H] (CC2) NC (=O) C2=NNC (CC3=CC=CC=C3) =N2) C (F) =C1
Molecular Formula
C20H17F2N5O2
Molecular Weight
397.38
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.

Alternative Products

CatalogName
BA3501-5.1GSK3145095
A19427-50GSK3145095 50mg
A19427-10GSK3145095 10mg
A19427-100GSK3145095 100mg
A19427-25GSK3145095 25mg
A19427-5GSK3145095 5mg
A19427-1GSK3145095 1mg
A19427-10mM-DGSK3145095 10mM * 1mL in DMSO

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